Venkataramani Lab

Innovating at the Interface of Cancer and Neuroscience.

Publications

Highlights

Schubert MC, Soyka SJ, Tamimi A, Maus E, Denninger R, Wissmann N, E. Reyhan, S. K. Tetzlaff, C. Beretta, M. Drumm, J. Schroers, A. Steffens, J. Walshon, K. McCortney, S. Heiland, A. Golebiewska, F. T. Kurz, W. Wick, F. Winkler, A. Kreshuk, T. Kuner, C. Horbinski, R. Prevedel and V. Venkataramani. Deep intravital brain tumor imaging enabled by tailored three-photon microscopy and analysis. bioRxiv. 2023:2023.06.17.545350. doi: 10.1101/2023.06.17.545350.

Venkataramani V, Yang Y, Schubert MC, Reyhan E, Tetzlaff SK, Wißmann N, Botz M, Soyka SJ, Beretta CA, Pramatarov RL, Fankhauser L, Garofano L, Freudenberg A, Wagner J, Tanev DI, Ratliff M, Xie R, Kessler T, Hoffmann DC, Hai L, Dörflinger Y, Hoppe S, Yabo YA, Golebiewska A, Niclou SP, Sahm F, Lasorella A, Slowik M, Döring L, Iavarone A, Wick W, Kuner T, Winkler F. Glioblastoma hijacks neuronal mechanisms for brain invasion. Cell. 2022 Aug 4;185(16):2899-2917.e31. doi: 10.1016/j.cell.2022.06.054. Epub 2022 Jul 31. PMID: 35914528.

Venkataramani V, Tanev DI, Strahle C, Studier-Fischer A, Fankhauser L, Kessler T, Körber C, Kardorff M, Ratliff M, Xie R, Horstmann H, Messer M, Paik SP, Knabbe J, Sahm F, Kurz FT, Acikgöz AA, Herrmannsdörfer F, Agarwal A, Bergles DE, Chalmers A, Miletic H, Turcan S, Mawrin C, Hänggi D, Liu HK, Wick W, Winkler F, Kuner T. Glutamatergic synaptic input to glioma cells drives brain tumour progression. Nature. 2019 Sep;573(7775):532-538. doi: 10.1038/s41586-019-1564-x. Epub 2019 Sep 18. PMID: 31534219.

2023

Schubert MC, Soyka SJ, Tamimi A, Maus E, Denninger R, Wissmann N, E. Reyhan, S. K. Tetzlaff, C. Beretta, M. Drumm, J. Schroers, A. Steffens, J. Walshon, K. McCortney, S. Heiland, A. Golebiewska, F. T. Kurz, W. Wick, F. Winkler, A. Kreshuk, T. Kuner, C. Horbinski, R. Prevedel and V. Venkataramani. Deep intravital brain tumor imaging enabled by tailored three-photon microscopy and analysis. bioRxiv. 2023:2023.06.17.545350. doi: 10.1101/2023.06.17.545350.

Ratliff M, Karimian-Jazi K, Hoffmann DC, Rauschenbach L, Simon M, Hai L, Mandelbaum H, Schubert MC, Kessler T, Uhlig S, Azorin DD, Jung E, Osswald M, Solecki G, Maros ME, Venkataramani V, Glas M, Etminan N, Scheffler B, Wick W, Winkler F. Individual glioblastoma cells harbor both proliferative and invasive capabilities during tumor progression. Neuro Oncol. 2023 Jun 19:noad109. doi: 10.1093/neuonc/noad109. Epub ahead of print. PMID: 37335907.

Venkataramani V. IGSF3-mediated potassium dysregulation promotes neuronal hyperexcitability and glioma progression. Trends Cancer. 2023 Jun;9(6):457-458. doi: 10.1016/j.trecan.2023.04.005. Epub 2023 Apr 24. PMID: 37100731.

Karreman MA, Bauer AT, Solecki G, Berghoff AS, Mayer CD, Frey K, Hebach N, Feinauer MJ, Schieber NL, Tehranian C, Mercier L, Singhal M, Venkataramani V, Schubert MC, Hinze D, Hölzel M, Helfrich I, Schadendorf D, Schneider SW, Westphal D, Augustin HG, Goetz JG, Schwab Y, Wick W, Winkler F. Active Remodeling of Capillary Endothelium via Cancer Cell-Derived MMP9 Promotes Metastatic Brain Colonization. Cancer Res. 2023 Apr 14;83(8):1299-1314. doi: 10.1158/0008-5472.CAN-22-3964. PMID: 36652557; PMCID: PMC7614438.

Drexler R, Göttsche J, Sauvigny T, Schüller U, Khatri R, Hausmann F, Hänzelmann S, Huber TB, Bonn S, Heiland DH, Delev D, Venkataramani V, Winkler F, Weller J, Zeyen T, Herrlinger U, Gempt J, Ricklefs FL, Dührsen L. Targeted anticonvulsive treatment of IDH-wildtype glioblastoma based on DNA methylation subclasses. Neuro Oncol. 2023 May 4;25(5):1006-1008. doi: 10.1093/neuonc/noad014. PMID: 36860191; PMCID: PMC10158071.

Winkler F, Venkatesh HS, Amit M, Batchelor T, Demir IE, Deneen B, Gutmann DH, Hervey-Jumper S, Kuner T, Mabbott D, Platten M, Rolls A, Sloan EK, Wang TC, Wick W, Venkataramani V, Monje M. Cancer neuroscience: State of the field, emerging directions. Cell. 2023 Apr 13;186(8):1689-1707. doi: 10.1016/j.cell.2023.02.002. PMID: 37059069; PMCID: PMC10107403.

2022

Hausmann D, Hoffmann DC, Venkataramani V, Jung E, Horschitz S, Tetzlaff SK, Jabali A, Hai L, Kessler T, Azoŕin DD, Weil S, Kourtesakis A, Sievers P, Habel A, Breckwoldt MO, Karreman MA, Ratliff M, Messmer JM, Yang Y, Reyhan E, Wendler S, Löb C, Mayer C, Figarella K, Osswald M, Solecki G, Sahm F, Garaschuk O, Kuner T, Koch P, Schlesner M, Wick W, Winkler F. Autonomous rhythmic activity in glioma networks drives brain tumour growth. Nature. 2023 Jan;613(7942):179-186. doi: 10.1038/s41586-022-05520-4. Epub 2022 Dec 14. PMID: 36517594.

Venkataramani V. Shining a light on tumour behaviour. Nat Rev Cancer. 2022 Dec;22(12):662. doi: 10.1038/s41568-022-00526-6. PMID: 36216887.

Yang Y, Schubert MC, Kuner T, Wick W, Winkler F, Venkataramani V. Brain Tumor Networks in Diffuse Glioma. Neurotherapeutics. 2022 Oct;19(6):1832-1843. doi: 10.1007/s13311-022-01320-w. Epub 2022 Nov 10. PMID: 36357661; PMCID: PMC9723066.

Venkataramani V, Winkler F. Cognitive Deficits in Long Covid-19. N Engl J Med. 2022 Nov 10;387(19):1813-1815. doi: 10.1056/NEJMcibr2210069. PMID: 36351274.

Venkataramani V, Winkler F. Krebsneurowissenschaft [Cancer Neuroscience]. Nervenarzt. 2022 Oct;93(10):977-986. German. doi: 10.1007/s00115-022-01380-5. Epub 2022 Sep 21. PMID: 36129477.

Venkataramani V, Schneider M, Giordano FA, Kuner T, Wick W, Herrlinger U, Winkler F. Disconnecting multicellular networks in brain tumours. Nat Rev Cancer. 2022 Aug;22(8):481-491. doi: 10.1038/s41568-022-00475-0. Epub 2022 Apr 29. PMID: 35488036.

Venkataramani V, Yang Y, Schubert MC, Reyhan E, Tetzlaff SK, Wißmann N, Botz M, Soyka SJ, Beretta CA, Pramatarov RL, Fankhauser L, Garofano L, Freudenberg A, Wagner J, Tanev DI, Ratliff M, Xie R, Kessler T, Hoffmann DC, Hai L, Dörflinger Y, Hoppe S, Yabo YA, Golebiewska A, Niclou SP, Sahm F, Lasorella A, Slowik M, Döring L, Iavarone A, Wick W, Kuner T, Winkler F. Glioblastoma hijacks neuronal mechanisms for brain invasion. Cell. 2022 Aug 4;185(16):2899-2917.e31. doi: 10.1016/j.cell.2022.06.054. Epub 2022 Jul 31. PMID: 35914528.

2021

Venkataramani V, Winkler F. Activation of retinal neurons triggers tumour formation in cancer-prone mice. Nature. 2021 Jun;594(7862):179-180. doi: 10.1038/d41586-021-01353-9. PMID: 34040239.

Xie R, Kessler T, Grosch J, Hai L, Venkataramani V, Huang L, Hoffmann DC, Solecki G, Ratliff M, Schlesner M, Wick W, Winkler F. Tumor cell network integration in glioma represents a stemness feature. Neuro Oncol. 2021 May 5;23(5):757-769. doi: 10.1093/neuonc/noaa275. PMID: 33320195; PMCID: PMC8099480.

Feinauer MJ, Schneider SW, Berghoff AS, Robador JR, Tehranian C, Karreman MA, Venkataramani V, Solecki G, Grosch JK, Gunkel K, Kovalchuk B, Mayer FT, Fischer M, Breckwoldt MO, Brune M, Schwab Y, Wick W, Bauer AT, Winkler F. Local blood coagulation drives cancer cell arrest and brain metastasis in a mouse model. Blood. 2021 Mar 4;137(9):1219-1232. doi: 10.1182/blood.2020005710. PMID: 33270819.

2020

Klevanski M, Herrmannsdoerfer F, Sass S, Venkataramani V, Heilemann M, Kuner T. Automated highly multiplexed super-resolution imaging of protein nano-architecture in cells and tissues. Nat Commun. 2020 Mar 25;11(1):1552. doi: 10.1038/s41467-020-15362-1. PMID: 32214101; PMCID: PMC7096454.

Venkataramani V, Tanev DI, Kuner T, Wick W, Winkler F. Synaptic input to brain tumors: clinical implications. Neuro Oncol. 2021 Jan 30;23(1):23-33. doi: 10.1093/neuonc/noaa158. PMID: 32623467; PMCID: PMC7850064.

2019

Portela M, Venkataramani V, Fahey-Lozano N, Seco E, Losada-Perez M, Winkler F, Casas-Tintó S. Glioblastoma cells vampirize WNT from neurons and trigger a JNK/MMP signaling loop that enhances glioblastoma progression and neurodegeneration. PLoS Biol. 2019 Dec 17;17(12):e3000545. doi: 10.1371/journal.pbio.3000545. PMID: 31846454; PMCID: PMC6917273.

Venkataramani V, Tanev DI, Strahle C, Studier-Fischer A, Fankhauser L, Kessler T, Körber C, Kardorff M, Ratliff M, Xie R, Horstmann H, Messer M, Paik SP, Knabbe J, Sahm F, Kurz FT, Acikgöz AA, Herrmannsdörfer F, Agarwal A, Bergles DE, Chalmers A, Miletic H, Turcan S, Mawrin C, Hänggi D, Liu HK, Wick W, Winkler F, Kuner T. Glutamatergic synaptic input to glioma cells drives brain tumour progression. Nature. 2019 Sep;573(7775):532-538. doi: 10.1038/s41586-019-1564-x. Epub 2019 Sep 18. PMID: 31534219.

Breckwoldt MO, Bode J, Sahm F, Krüwel T, Solecki G, Hahn A, Wirthschaft P, Berghoff AS, Haas M, Venkataramani V, von Deimling A, Wick W, Herold-Mende C, Heiland S, Platten M, Bendszus M, Kurz FT, Winkler F, Tews B. Correlated MRI and Ultramicroscopy (MR-UM) of Brain Tumors Reveals Vast Heterogeneity of Tumor Infiltration and Neoangiogenesis in Preclinical Models and Human Disease. Front Neurosci. 2019 Jan 10;12:1004. doi: 10.3389/fnins.2018.01004. PMID: 30686972; PMCID: PMC6335617.

2018

Venkataramani V, Kardorff M, Herrmannsdörfer F, Wieneke R, Klein A, Tampé R, Heilemann M, Kuner T. Enhanced labeling density and whole-cell 3D dSTORM imaging by repetitive labeling of target proteins. Sci Rep. 2018 Apr 3;8(1):5507. doi: 10.1038/s41598-018-23818-0. PMID: 29615726; PMCID: PMC5882651.

2017

Herrmannsdörfer F, Flottmann B, Nanguneri S, Venkataramani V, Horstmann H, Kuner T, Heilemann M. 3D d STORM Imaging of Fixed Brain Tissue. Methods Mol Biol. 2017;1538:169-184. doi: 10.1007/978-1-4939-6688-2_13. PMID: 27943191.

2016

Venkataramani V, Herrmannsdörfer F, Heilemann M, Kuner T. SuReSim: simulating localization microscopy experiments from ground truth models. Nat Methods. 2016 Apr;13(4):319-21. doi: 10.1038/nmeth.3775. Epub 2016 Feb 29. PMID: 26928761.

2015

Osswald M, Jung E, Sahm F, Solecki G, Venkataramani V, Blaes J, Weil S, Horstmann H, Wiestler B, Syed M, Huang L, Ratliff M, Karimian Jazi K, Kurz FT, Schmenger T, Lemke D, Gömmel M, Pauli M, Liao Y, Häring P, Pusch S, Herl V, Steinhäuser C, Krunic D, Jarahian M, Miletic H, Berghoff AS, Griesbeck O, Kalamakis G, Garaschuk O, Preusser M, Weiss S, Liu H, Heiland S, Platten M, Huber PE, Kuner T, von Deimling A, Wick W, Winkler F. Brain tumour cells interconnect to a functional and resistant network. Nature. 2015 Dec 3;528(7580):93-8. doi: 10.1038/nature16071. Epub 2015 Nov 4. PMID: 26536111.

Körber C, Horstmann H, Venkataramani V, Herrmannsdörfer F, Kremer T, Kaiser M, Schwenger DB, Ahmed S, Dean C, Dresbach T, Kuner T. Modulation of Presynaptic Release Probability by the Vertebrate-Specific Protein Mover. Neuron. 2015 Aug 5;87(3):521-33. doi: 10.1016/j.neuron.2015.07.001. Epub 2015 Jul 23. PMID: 26212709.

2013

Bali KK, Venkataramani V, Satagopam VP, Gupta P, Schneider R, Kuner R. Transcriptional mechanisms underlying sensitization of peripheral sensory neurons by granulocyte-/granulocyte-macrophage colony stimulating factors. Mol Pain. 2013 Sep 25;9:48. doi: 10.1186/1744-8069-9-48. PMID: 24067145; PMCID: PMC3852053.